I'll throw a bit of information in here for you.

Currently, the system is very "twitch" in that you can attack as fast as your weapon/attack speed will allow it. Your attack speed can be slowed down or sped up from items and abilities as well. This, however, doesn't mean that you should necessarily click as fast as you can.

The strategic portion of your basic attacks (lovingly called BAMs) is deciding when to click: Do I wait for my offensive percentage to get as high as it can before I attack (giving me a greater % chance to hit) or am I just going to pound on this creature as fast as I can, throwing caution to the wind and possibly eating up more of my precious power.

Defensive strategy comes into play when you decide if you want to use power to defend or save that power for a devastating blow to your opponent.

The strategy from your Power Moves (lovingly called POWs) a.k.a. "Abilities", comes into play constantly:
1) Am I going to use an ability that will interrupt my target
2) Outright stop my target from using abilities for a duration.
3) Use a radius effect ability and possibly get lots of love from all enemies around me.
4) Heal myself/party members.

You get the idea.

Jon and/or the designers can chime in here if I missed something, but, that is the basic premise behind our combat system.

Does this help any?

- Kevin "Jalek" Saffel
Life would be much easier if I had the source code...